Definition of Advanced Cell Therapy Trials:

We define Advanced Cell Therapy as all therapies in which cells are more than minimally manipulated, and/or their action is not homologous.

Our definition is similar to the European Medicines Agency (EMA) definition of Advanced Therapy Medicinal Product (ATMP): “Medicinal product for human use that is a gene therapy medicinal product, a somatic cell therapy medicinal product or tissue engineered product” (EMA ATMP Reg. No. 1394/2007)

The definition of Advanced Cell Therapy overlaps with, but is not the same as, Regenerative Medicine, which is defined as therapy that "replaces or regenerates human cells, tissue or organs, to restore or establish normal function" (Mason & Dunnil 2008)

Advanced Cell Therapy encompasses Regenerative Medicine with cells, and in addition includes Cellular Immunotherapy, Gene Therapy that is delivered by cells, and Tissue Engineering that is seeded or administered with cells.

Note that Advanced Cell Therapy does not include Hematopoietic Stem Cell Transplants (HSCT), unless the cells are more than minimally manipulated before they are administered. Advanced Cell Therapy does not include Gene Therapy or Tissue Engineering that does not employ cells.

Please bear in mind that the other compilations in our comparison table each have their own selection criteria for compiling trials.


AEAdverse Events
ALDHbr cellsAldehyde Dehydrogenase Bright Cells
ALLAcute Lymphoblastic Leukemia
AMLAcute Myeloid Leukemia
APHApheresis (leukapheresis)
ATAdipose Tissue
BMBone Marrow
BMACBone Marrow Aspirate Concentrate
CARChimeric Antigen Receptors
CBCord Blood
CIKCytokine-induced Killer Cells
CLLChronic Lymphocytic Leukemia
CRComplete Remission
CRSCytokine Release Syndrome
CTLCytotoxic T Lymphocytes
DCDendritic Cells
DLBCLDiffuse Large B Cell Lymphoma
DLCLDiffuse Large Cell Lymphoma
DLIDonor Lymphocyte Infusion
DPDental Pulp
EPCEndothelial Progenitor Cells
ESCEmbryonic Stem Cells
FCRxFacilitating Cell Platform Technology (Hematopoietic Cells Bioengineered)
hRPE-ESCHuman Retinal Pigmented Epithelial- Embryonic Stem Cells
HSCHematopoietic Stem Cells
HSCTHematopoietic Stem Cell Transplant
HSPCHematopoietic Stem Progenitor Cells
HuCNS-SCHuman Central Nervous System-Stem Cells
lenti-lentiviral vector
MAPCMultipotent Adult Progenitor Cells
MILMarrow Infiltrating Lymphocytes
MNCMononuclear Cells
MRDMinimal Residual Disease
MSCMesenchymal Stem/Stromal Cells
NHLNon-Hodgkins Lymphoma
NKNatural Killer cells
NKTNatural Killer T-Cell
ORROverall/Objective Response Rate
OSOverall Survival
PBPeripheral Blood
PDProgressive Disease
PRPartial Response
pedi-Pediatric Patients
PFSProgression-Free Survival
PLLProLymphocytic Leukemia
retro-retroviral vector
RPE-iPSRetinal Pigmented Epithelial-induced Pluripotent Stem Cells
SDStable Disease
SLLSmall Lymphocytic Lymphoma
SVFStromal Vascular Fraction
TCRT-Cell Receptor
TILTumor-infiltrating lymphocytes
UCUmbilical Cord
VSTVirus-Specific T-Cell