Compilations of Cell Therapy Clinical Trials

#	Number of Trials	Last Trial Year	Trials by Year?	Cell Types	Therapy Types	Trial Registries	Name and Reference
1	6470	2021	YES	ALL	ALL	ClinicalTrials.gov & WHO registries	CellTrials.org Cell Trials Data by Bersenev, Couto, Verter Link: https://celltrials.org/cells-data Format: Website Years Covered: Jan. 2011 - Dec. 2021 Search Strategy: Manually search over a dozen registries by keywords Project Focus: any trials of advanced cell therapy, worldwide
2	152	2015	YES	SVF-MSC	ALL	ClinicalTrials.gov	Nordberg RC, and Loboa EG. Stem Cells Transl Med. 2015; 4(9):974–979 Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542878/ Format: Publication Years Covered: Cumulative to 2015/03/09 Search Strategy: Manually search registry by keywords Project Focus: SVF-MSC trials only from ClinicalTrials.gov Special Notes: provides database of companies and patents
3	281	2015	YES	Perinatal	ALL	ClinicalTrials.gov & WHO registries	Couto PS, Bersenev A, Verter F. Regenerative Medicine 2017; 12(8):953-968 Link: https://www.futuremedicine.com/doi/pdf/10.2217/rme-2017-0066 Format: Publication Years Covered: Jan. 2005 - Dec. 2015 Search Strategy: Manually search a dozen registries by keywords Project Focus: Trials of perinatal cells for advanced cell therapy, worldwide Special Notes: First paper on first decade of perinatal advanced cell therapy
4	800	2017	YES	MSC	ALL	ClinicalTrials.gov	TerumoBCT Clinical Trial Visualization Tool Link: https://www.terumobct.com/cell-therapy-technologies/clinical… Format: Website Years Covered: Cumulative to 2017/02/01 Search Strategy: Software search registry by keywords, augmented by human evaluation Project Focus: MSC trials only from ClinicalTrials.gov Special Notes: on-line sort by 6 parameters
5	177	2015	NO	SVF-MSC	ALL	ClinicalTrials.gov	Feisst V, Meidinger S, Locke MB. Stem Cells Cloning 2015; 8:149–162 Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636091/ Format: Publication Years Covered: Cumulative to May 2015 Search Strategy: Manually search registry by keywords Project Focus: SVF-MSC trials only from ClinicalTrials.gov Special Notes: found 177 trials, 89 with status Open
6	1710	2021	YES	MSC	ALL	ClinicalTrials.gov & WHO registries	CellTrials.org Cell Trials Data MSC Link: https://celltrials.org/cells-data Format: Website Years Covered: Jan. 2011 - Dec. 2021 Search Strategy: Manually search over a dozen registries by keywords Project Focus: 15-16 parameters for all trials with isolated MSC from any source
7	154	2020	YES	ALL	ALL	UK Catapult	Cell and Gene Therapy Catapult Link: https://ct.catapult.org.uk/resources/cell-and-gene-therapy-c… Format: Website Years Covered: CURRENTLY ACTIVE trials in UK through end of 2020 Search Strategy: Not disclosed Project Focus: advanced cell therapy, active that year, in the UK only Special Notes: Table of 15 parameters per trial, overview statistics, archives to 2012.
8	178	2017	YES	UC-MSC	ALL	ClinicalTrials.gov & WHO registries	Couto PS, Shatirishvili G, Bersenev A, Verter F. Regenerative Medicine 2019; open access Link: https://www.futuremedicine.com/doi/full/10.2217/rme-2018-017… Format: Publication Years Covered: Jan. 2007 - Dec. 2017 Search Strategy: Manually search a dozen registries by keywords Project Focus: Link first decade of UC-MSC trials to UC-MSC publications Special Notes: First review of manufacturing methods in UC-MSC publications
9	196	2013	YES	ALL	ALL	ClinicalTrials.gov	The Stem Cell Stock Index by Busa Consulting Link: http://busaconsultingllc.com/scsi/organelles/2013_clinical_t… Link: http://busaconsultingllc.com/scsi/organelles/2013_clinical_t… Format: Website Years Covered: Cumulative from 1998 to 2013/08/31 Search Strategy: Manually search registry by keywords Project Focus: only trials sponsored by industry Special Notes: on-line heat-map display
10	914	2018	YES	MSC	ALL	ClinicalTrials.gov	Kabat M, Bobkov I, Kumar S, Grumet M. Stem Cells Translatonal Medicine 2020; 9(1):17-27 Link: https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/1… Format: Publication Years Covered: 2004 - 2018 Search Strategy: Manually search registry by keywords Project Focus: MSC trials only from ClinicalTrials.gov Special notes: Analysis Route of Admin versus Dose
11	123	2011	NO	MSC	ALL	ClinicalTrials.gov	Trounson A et al. BMC Medicine 2011; DOI:10.1186/1741-7015-9-52 Link: http://bmcmedicine.biomedcentral.com/articles/10.1186/1741-7… Format: Publication Years Covered: Cumulative to 2011/02/08 Search Strategy: Manually search registry by keywords Project Focus: MSC trials only from ClinicalTrials.gov
12	939	2015	partialYES	ALL	ALL	ClinicalTrials.gov	Monsarrat P et al. Stem Cells Transl Med 2016; 5(6):826-35 Link: http://stemcellstm.alphamedpress.org/content/early/2016/04/1… Link: http://multireview.perso.sfr.fr Format: Publication Years Covered: Cumulative to 2015/06/29 Search Strategy: Software search registry by MeSH code Project Focus: all trials from ClinicalTrials.gov Special Notes: companion website available for MeSH search, time trends combine multiple years, among 939 trials 51.1% (480) were cell type MSC
13	493	2015	NO	MSC	ALL	ClinicalTrials.gov	Squillaro T, Peluso G, Galderisi U. 2016; Cell Transplantation 25:829-848 Link: https://journals.sagepub.com/doi/full/10.3727/096368915X6896… Format: Publication Years Covered: Cumulative to 2015/06/15 Search Strategy: Manually search registry by keywords Project Focus: MSC trials only from ClinicalTrials.gov
14	318	2010	NO	ALL	ALL	EudraCT	Maciulaitis R et al. Mol Ther. 2012; 20(3):479-82. Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293601/ Format: Publication Years Covered: May 2004 - Dec 2010 Search Strategy: Manually search registry by keywords Project Focus: EU trials only
15	416	2017	YES	Perinatal	ALL	ClinicalTrials.gov & WHO registries	Verter F, Couto PS, Bersenev A. Future Science 2018; 4(10):Editorial Link: https://www.future-science.com/doi/full/10.4155/fsoa-2018-00… Format: Publication Years Covered: Jan. 2005 - Dec. 2017 Search Strategy: Manually search a dozen registries by keywords Project Focus: Trials of perinatal cells for advanced cell therapy, worldwide
16	1716	2010	NO	ALL	ALL	ClinicalTrials.gov	Culme-Seymour EJ et al. Regenerative Medicine 2012; 7(4):455-462 Link: http://www.futuremedicine.com/doi/full/10.2217/rme.12.45 Format: Publication Years Covered: Feb 2000 - June 2010 Search Strategy: Manually search registry by keywords Project Focus: Decadal review ClinicalTrials.gov Special Notes: Found 2724 cell therapy trials total, eliminate 37% (1008) that are "conventional grafts"
17	278	2014	NO	ALL	ALL	EudraCT	de Wilde S, et al. Mol Ther Methods Clin Dev. 2016; 3:16073. Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130079/ Format: Publication Years Covered: 2004 - 2014 Search Strategy: Manually search registry by keywords Project Focus: Decadal review of EU trials only Special Notes: 278 trials covered 198 products
18	103	2013	NO	ALL	ALL	Misc.	Ratcliffe E. et al. Br Med Bull 2013; 108:73-94 Link: http://bmb.oxfordjournals.org/content/early/2013/11/07/bmb.l… Format: Format: Publication Years Covered: Cumulative to April 2013 Search Strategy: Manually search USA FDA CBER report & UK Catapult database Project Focus: trials review USA & UK trials only
19	109	2016	NO	UC-MSC	ALL	ClinicalTrials.gov	Davies J, Walker JT, Keating A. Stem Cells Trans Med 2017; 6(7):1620-1630 Link: http://onlinelibrary.wiley.com/doi/10.1002/sctm.16-0492/full Format: Publication Years Covered: 2009 - 2016 Search Strategy: Manually search registry by keywords Project Focus: Trials that employ umbilical cord tissue MSC
20	218	2012	NO	MSC	ALL	ClinicalTrials.gov	Sharma et al. Transfusion 2013; 54(5):1418–1437 Link: http://onlinelibrary.wiley.com/doi/10.1111/trf.12421/full Format: Publication Years Covered: Cumulative to 2012/10/22 Search Strategy: Manually search registry by keywords Project Focus: MSC trials only from ClinicalTrials.gov
21	106	2016	NO	CAR-T	ALL	ClinicalTrials.gov & EudraCT	de Wilde S, et al. Cytotherapy 2017; 19(6):703-709 Link: http://www.celltherapyjournal.org/article/S1465-3249(17)3052… Format: Publication Years Covered: Cumulative to June 2016 Search Strategy: Manually search registries by keywords Project Focus: Only CAR-T trials conducted in Canada, US, EU Special Notes: 49 of 106 trials moved to subsequent trial
22	1014	2021	YES	MSC	ALL	ClinicalTrials.gov	Jovic D, et al. Stem Cell Reviews and Reports 2022; Link: https://link.springer.com/article/10.1007/s12015-022-10369-1 Format: Publication Years Covered: Cumulative to 2021/07/14 Search Strategy: Manually search registry by keywords Project Focus: MSC trials only from ClinicalTrials.gov
23	344	2012	YES	MSC	ALL	ClinicalTrials.gov	Wei X et al. Acta Pharmacologica Sinica 2013; 34:747–754 Link: http://www.nature.com/aps/journal/v34/n6/abs/aps201350a.html Format: Publication Years Covered: 2004 - 2012 Search Strategy: Manually search registry by keywords Project Focus: MSC trials only from ClinicalTrials.gov
24	1198	2020	YES	CAR-T	ALL	ClinicalTrials.gov & WHO registries	CellTrials.org Cell Trials Data CAR-T Link: https://celltrials.org/public-cells-data/car-immunotherapy-t… Format: Website Years Covered: Cumulative through December 2020 Search Strategy: Manually search a dozen registries by keywords Project Focus: 22 parameters for all CAR-T trials to date
25	347	2013	YES	MSC	ALL	ClinicalTrials.gov	Ankrum JA, Ong JF, Karp JM. Nat Biotechnol. 2014 Mar; 32(3):252–260 Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320647/ Format: Publication Years Covered: 2000 - 2013 Search Strategy: Manually search registry by keywords Project Focus: 14yrs MSC trials only from ClinicalTrials.gov
26	1052	2012	NO	None	ALL	ClinicalTrials.gov & WHO registries	Fung M et al. 2017; Stem Cell Reports 8:1190-1201 Link: http://www.cell.com/stem-cell-reports/pdf/S2213-6711(17)3011… Format: Publication Years Covered: 1992 - 2012 Search Strategy: Seek publications and outcomes from trials in Li, Atkins, Bubela 2014 Project Focus: Follow up to prior trial compilation to learn how many regenerative medicine trials completed (37.4%), and published (45.4% of completed), and did the trials follow ISSCR guidelines? Special Notes: This study is 1st of its kind.
27	220	2016	YES	CAR-T	ALL	ClinicalTrials.gov	Hartmann J et al. EMBO Molecular Medicine 2017; e201607485 Link: http://embomolmed.embopress.org/content/early/2017/07/31/emm… Format: Publication Years Covered: Cumulative to end of 2016 Search Strategy: Manually search registry by keywords Project Focus: Review of CAR-T trials, distinguishes ongoing from non-active trials, includes trial outcomes, provides download of the 220 trials with 10 parameters per trial Special Notes: First trial compilation ever to give away raw trial data.
28	41	2014	NO	ALL	ALL	UK Catapult	Bisson I et al. Regenerative Medicine 2015; 10(2):169-179 Link: http://www.futuremedicine.com/doi/abs/10.2217/rme.14.71 Format: Publication Years Covered: April 2013 - March 2014 Search Strategy: Manually search 4 registries by keywords Project Focus: Only UK trials with status Open Special Notes: Build UK Catapult from searches of USA:ClinicalTrials.gov, UK:ISRCTN, UK:CRN, EudraCT
29	124	2020	NO	Cord Blood	ALL	ClinicalTrials.gov & WHO registries	Recruiting Trials: Cord Blood from Parent's Guide to Cord Blood Link: https://parentsguidecordblood.org/en/trials Format: Website Years Covered: Cumulative to 30 April 2020 Search Strategy: Manually search a dozen registries by keywords Project Focus: On-line search portal of all currently recruiting cord blood trials, both advanced cell therapy and standard hematology/oncology, worldwide
30	724	2014	NO	ALL	ALL	ClinicalTrials.gov	Heathman TRJ et al. Regenerative Medicine 2015; 10(1):49-64 Link: http://www.futuremedicine.com/doi/full/10.2217/rme.14.73 Format: Publication Years Covered: Cumulative to 2014 Search Strategy: Manually search registry by keywords Project Focus: all cell therapy trials in ClinicalTrials.gov Special Notes: Found 1342 cell therapy trials with status Open, eliminate 46% (618) that are "oncology"
31	469	2014	NO	see notes	ALL	Misc.	Trounson A, McDonald C. Cell Stem Cell 2015; 17(1):11-22 Link: http://www.sciencedirect.com/science/article/pii/S1934590915… Format: Publication Years Covered: not disclosed Search Strategy: Searched publications to find trials Project Focus: trials are listed for the 3 cell types ESC, placental, neural
32	155	2020	NO	UC-MSC	ALL	ClinicalTrials.gov & WHO registries	Recruiting Trials: Umbilical Cord Tissue from Parent's Guide to Cord Blood Link: https://parentsguidecordblood.org/en/trials-umbilical-cord-t… Format: Website Years Covered: Cumulative to 30 April 2020 Search Strategy: Manually search a dozen registries by keywords Project Focus: On-line search portal of all currently recruiting trials that employ umbilical cord tissue MSC
33	34	2014	NO	MSC	cardiac	ClinicalTrials.gov	Sanina C, Hare JM. Circulation Research. 2015;117:229-233 Link: http://circres.ahajournals.org/content/117/3/229.short Format: Publication Years Covered: not disclosed Search Strategy: Manually search registry by keywords Project Focus: MSC cardiac trials only from ClinicalTrials.gov
34	41	2015	NO	MSC	cardiac	ClinicalTrials.gov	Singh A, Singh A, Sen D. Stem Cell Research & Therapy (2016) 7:82 Link: http://stemcellres.biomedcentral.com/articles/10.1186/s13287… Format: Publication Years Covered: 2010 - 2015 Project Focus: MSC cardiac trials only from ClinicalTrials.gov Special Notes: open source article has link to download table of all trials
35	39	2015	NO	MSC	pediatric	Misc.	Nitkin CR, Bonfield TL. Stem Cells Transl Med 2017; 6(2):539–565 Link: http://onlinelibrary.wiley.com/doi/10.5966/sctm.2015-0427/fu… Format: Publication Years Covered: 2002 - 2015 Search Strategy: Searched publications to find trials Project Focus: MSC pediatric trials only Special Notes: among 39 trials only 13 are registered
36	12	2016	YES	AT-MSC	aesthetic surgery	ClinicalTrials.gov &WHO registries	Arshad Z, et al. Aesthet Surg J 2017; epub Link: https://www.ncbi.nlm.nih.gov/pubmed/28591768 Format: Publication Years Covered: Cumulative to 2016/12/31 Search Strategy: Manually search all world registries by keywords Project Focus: only AT-MSC trials for aesthetic surgery Special Notes: supplement provides 115 patent applications 2002-2016
37	1058	2012	YES	ALL	novel	ClinicalTrials.gov &WHO registries	Li MD, Atkins H, Bubela T. Regenerative Medicine 2014; 9(1):27-39 Link: http://www.futuremedicine.com/doi/full/10.2217/rme.13.80 Format: Publication Years Covered: 1992 - 2012 Search Strategy: Manually search registries by keywords Project Focus: Two Decades review of the world Special Notes: Found 4749 cell therapy trials total, but only 1058 are "novel" therapy
38	47	2013	NO	Cord Blood	novel	Misc.	Iafolla MA, Tay J, Allan DS. Biol Blood Marrow Transplant. 2014; 20(1):20-25 Link: http://www.bbmt.org/article/S1083-8791(13)00409-6/fulltext Format: Publication Years Covered: Cumulative to 2013 Search Strategy: Searched publications to find trials Project Focus: Cord Blood trials, "novel" therapy, status Open, registered anywhere
39	57	2016	NO	Cord Blood	novel	Misc.	Rizk M et al. Biol Blood Marrow Transplant. 2017; 23(10):1607-1613 Link: http://www.sciencedirect.com/science/article/pii/S1083879117… Format: Publication Years Covered: Cumulative to June 2016 Search Strategy: Searched publications to find trials Project Focus: Cord Blood trials, "novel" therapy, registered anywhere
40	1579	2015	YES	ALL	immuno-therapy	ClinicalTrials.gov & WHO registries	Bonter K, ... Bubela T. Regenerative Medicine 2017; 12(6):623-636 Link: https://www.futuremedicine.com/doi/pdfplus/10.2217/rme-2017-… Format: Publication Years Covered: 1974 - 2015 Search Strategy: Computer search registries by keywords, followed with manual review Project Focus: Trends in immunotherapy, especially academic versus industry development Special Notes: Trial screening identified "interventional trials" that measure at least one: safety, tolerability, efficacy.
41	593	2019	YES	CAR-T	oncology	ClinicalTrials.gov	Moreno-Cortes E et al. Critical Reviews Onc/Hem 2021; 159:103239 Link: https://www.sciencedirect.com/science/article/abs/pii/S10408… Format: Publication Years Covered: Cumulative through December 2019 Search Strategy: Manually search registry by keywords Project Focus: CAR-T trials only from ClinicalTrials.gov Special Notes: This paper has several novel ways of analyzing the data, such as number of CAR-T trials for each antigen target.
42	284	2021	NO	None	in vivo gene therapy	ClinicalTrials.gov	Zhao Z, Anselmo AC, Mitragotri S. Bioeng. Transl. Med. 2022; 7(1):e10528 Link: https://aiche.onlinelibrary.wiley.com/doi/full/10.1002/btm2.… Format: Publication Years Covered: 2021 Search Strategy: Manually search registries by keywords Project Focus: Active in vivo gene therapy trials as of March 2021 Special Notes: Detailed review of all viral vectors in clinical trials
43	879	2021	YES	None	in vivo gene therapy	ClinicalTrials.gov & WHO registries	CellTrials.org in vivo gene therapy by Stibbs Link: https://celltrials.org/public-cells-data/subscribe-to-gene-t… Format: Website Years Covered: Jan. 2011 - Dec. 2021 Search Strategy: Manually search registries by keywords Project Focus: Any trials in vivo gene therapy worldwide Special Notes: First database of in vivo gene therapy trials versus time
44	2597	2017	YES	varies	gene therapy	ClinicalTrials.gov & WHO registries	Ginn SL, et al. J Gene Medicine 2018; 20(5):e3015 Link: https://onlinelibrary.wiley.com/doi/abs/10.1002/jgm.3015 Format: Publication Years Covered: 1989 - 2017 Search Strategy: Manually search registries by keywords Project Focus: Review gene therapy trials combining cellular therapy and in vivo therapy
45	3180	2021	NO	varies	gene therapy	ClinicalTrials.gov & WHO registries	J Gene Therapy Searchable Database Link: https://a873679.fmphost.com/fmi/webd/GTCT Format: Website Years Covered: Cumulative to some time in 2021 Search Strategy: Unknown Project Focus: Website provides statistical summaries and allows trial search

Compilations of Cell Therapy Clinical Trials

CellTrials.org Cell Trials Data by Bersenev, Couto, Verter

Nordberg RC, and Loboa EG. Stem Cells Transl Med. 2015; 4(9):974–979

Couto PS, Bersenev A, Verter F. Regenerative Medicine 2017; 12(8):953-968

TerumoBCT Clinical Trial Visualization Tool

Feisst V, Meidinger S, Locke MB. Stem Cells Cloning 2015; 8:149–162

CellTrials.org Cell Trials Data MSC

Cell and Gene Therapy Catapult

Couto PS, Shatirishvili G, Bersenev A, Verter F. Regenerative Medicine 2019; open access

The Stem Cell Stock Index by Busa Consulting

Kabat M, Bobkov I, Kumar S, Grumet M. Stem Cells Translatonal Medicine 2020; 9(1):17-27

Trounson A et al. BMC Medicine 2011; DOI:10.1186/1741-7015-9-52

Monsarrat P et al. Stem Cells Transl Med 2016; 5(6):826-35

Squillaro T, Peluso G, Galderisi U. 2016; Cell Transplantation 25:829-848

Maciulaitis R et al. Mol Ther. 2012; 20(3):479-82.

Verter F, Couto PS, Bersenev A. Future Science 2018; 4(10):Editorial

Culme-Seymour EJ et al. Regenerative Medicine 2012; 7(4):455-462

de Wilde S, et al. Mol Ther Methods Clin Dev. 2016; 3:16073.

Ratcliffe E. et al. Br Med Bull 2013; 108:73-94

Davies J, Walker JT, Keating A. Stem Cells Trans Med 2017; 6(7):1620-1630

Sharma et al. Transfusion 2013; 54(5):1418–1437

de Wilde S, et al. Cytotherapy 2017; 19(6):703-709

Jovic D, et al. Stem Cell Reviews and Reports 2022;

Wei X et al. Acta Pharmacologica Sinica 2013; 34:747–754

CellTrials.org Cell Trials Data CAR-T

Ankrum JA, Ong JF, Karp JM. Nat Biotechnol. 2014 Mar; 32(3):252–260

Fung M et al. 2017; Stem Cell Reports 8:1190-1201

Hartmann J et al. EMBO Molecular Medicine 2017; e201607485

Bisson I et al. Regenerative Medicine 2015; 10(2):169-179

Recruiting Trials: Cord Blood from Parent's Guide to Cord Blood

Heathman TRJ et al. Regenerative Medicine 2015; 10(1):49-64

Trounson A, McDonald C. Cell Stem Cell 2015; 17(1):11-22

Recruiting Trials: Umbilical Cord Tissue from Parent's Guide to Cord Blood

Sanina C, Hare JM. Circulation Research. 2015;117:229-233

Singh A, Singh A, Sen D. Stem Cell Research & Therapy (2016) 7:82

Nitkin CR, Bonfield TL. Stem Cells Transl Med 2017; 6(2):539–565

Arshad Z, et al. Aesthet Surg J 2017; epub

Li MD, Atkins H, Bubela T. Regenerative Medicine 2014; 9(1):27-39

Iafolla MA, Tay J, Allan DS. Biol Blood Marrow Transplant. 2014; 20(1):20-25

Rizk M et al. Biol Blood Marrow Transplant. 2017; 23(10):1607-1613

Bonter K, ... Bubela T. Regenerative Medicine 2017; 12(6):623-636

Moreno-Cortes E et al. Critical Reviews Onc/Hem 2021; 159:103239

Zhao Z, Anselmo AC, Mitragotri S. Bioeng. Transl. Med. 2022; 7(1):e10528

CellTrials.org in vivo gene therapy by Stibbs

Ginn SL, et al. J Gene Medicine 2018; 20(5):e3015

J Gene Therapy Searchable Database