Compilations of Cell Therapy Clinical Trials

# Number of Trials Last Trial Year Trials by Year? Cell Types Therapy Types Trial Registries Name and Reference
1 7241 2022 YES ALL ALL ClinicalTrials.gov & WHO registries

CellTrials.org Cell Trials Data by Bersenev, Couto, Verter

Link: https://celltrials.org/cells-data

Format: Website
Years Covered: Jan. 2011 - Dec. 2022
Search Strategy: Manually search over a dozen registries by keywords
Project Focus: any trials of advanced cell therapy, worldwide

2 154 2022 YES ALL ALL UK Catapult

Cell and Gene Therapy Catapult

Link: https://ct.catapult.org.uk/resources/cell-and-gene-therapy-catapult-uk-clinical…

Format: Website
Years Covered: CURRENTLY ACTIVE trials in UK through end of 2022
Search Strategy: Not disclosed
Project Focus: advanced cell therapy, active that year, in the UK only
Special Notes: Table of 15 parameters per trial, overview statistics, archives to 2012.

3 879 2021 YES None in vivo gene therapy ClinicalTrials.gov & WHO registries

CellTrials.org in vivo gene therapy by Stibbs

Link: https://celltrials.org/public-cells-data/subscribe-to-gene-therapy-trials-2011-…

Format: Website
Years Covered: Jan. 2011 - Dec. 2021
Search Strategy: Manually search registries by keywords
Project Focus: Any trials in vivo gene therapy worldwide
Special Notes: First database of in vivo gene therapy trials versus time

4 3180 2021 NO varies gene therapy ClinicalTrials.gov & WHO registries

J Gene Therapy Searchable Database

Link: https://a873679.fmphost.com/fmi/webd/GTCT

Format: Website
Years Covered: Cumulative to some time in 2021
Search Strategy: Unknown
Project Focus: Website provides statistical summaries and allows trial search

5 284 2021 NO None in vivo gene therapy ClinicalTrials.gov

Zhao Z, Anselmo AC, Mitragotri S. Bioeng. Transl. Med. 2022; 7(1):e10528

Link: https://aiche.onlinelibrary.wiley.com/doi/full/10.1002/btm2.10258

Format: Publication
Years Covered: 2021
Search Strategy: Manually search registries by keywords
Project Focus: Active in vivo gene therapy trials as of March 2021
Special Notes: Detailed review of all viral vectors in clinical trials

6 1014 2021 YES MSC ALL ClinicalTrials.gov

Jovic D, et al. Stem Cell Reviews and Reports 2022;

Link: https://link.springer.com/article/10.1007/s12015-022-10369-1

Format: Publication
Years Covered: Cumulative to 2021/07/14
Search Strategy: Manually search registry by keywords
Project Focus: MSC trials only from ClinicalTrials.gov

7 1710 2021 YES MSC ALL ClinicalTrials.gov & WHO registries

CellTrials.org Cell Trials Data MSC

Link: https://celltrials.org/cells-data

Format: Website
Years Covered: Jan. 2011 - Dec. 2021
Search Strategy: Manually search over a dozen registries by keywords
Project Focus: 15-16 parameters for all trials with isolated MSC from any source

8 155 2020 NO UC-MSC ALL ClinicalTrials.gov & WHO registries

Recruiting Trials: Umbilical Cord Tissue from Parent's Guide to Cord Blood

Link: https://parentsguidecordblood.org/en/trials-umbilical-cord-tissue

Format: Website
Years Covered: Cumulative to 30 April 2020
Search Strategy: Manually search a dozen registries by keywords
Project Focus: On-line search portal of all currently recruiting trials that employ umbilical cord tissue MSC

9 124 2020 NO Cord Blood ALL ClinicalTrials.gov & WHO registries

Recruiting Trials: Cord Blood from Parent's Guide to Cord Blood

Link: https://parentsguidecordblood.org/en/trials

Format: Website
Years Covered: Cumulative to 30 April 2020
Search Strategy: Manually search a dozen registries by keywords
Project Focus: On-line search portal of all currently recruiting cord blood trials, both advanced cell therapy and standard hematology/oncology, worldwide

10 1198 2020 YES CAR-T ALL ClinicalTrials.gov & WHO registries

CellTrials.org Cell Trials Data CAR-T

Link: https://celltrials.org/public-cells-data/car-immunotherapy-trials/56

Format: Website
Years Covered: Cumulative through December 2020
Search Strategy: Manually search a dozen registries by keywords
Project Focus: 22 parameters for all CAR-T trials to date

11 593 2019 YES CAR-T oncology ClinicalTrials.gov

Moreno-Cortes E et al. Critical Reviews Onc/Hem 2021; 159:103239

Link: https://www.sciencedirect.com/science/article/abs/pii/S1040842821000275

Format: Publication
Years Covered: Cumulative through December 2019
Search Strategy: Manually search registry by keywords
Project Focus: CAR-T trials only from ClinicalTrials.gov
Special Notes: This paper has several novel ways of analyzing the data, such as number of CAR-T trials for each antigen target.

12 914 2018 YES MSC ALL ClinicalTrials.gov

Kabat M, Bobkov I, Kumar S, Grumet M. Stem Cells Translatonal Medicine 2020; 9(1):17-27

Link: https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/sctm.19-0202

Format: Publication
Years Covered: 2004 - 2018
Search Strategy: Manually search registry by keywords
Project Focus: MSC trials only from ClinicalTrials.gov
Special notes: Analysis Route of Admin versus Dose

13 800 2017 YES MSC ALL ClinicalTrials.gov

TerumoBCT Clinical Trial Visualization Tool

Link: https://www.terumobct.com/cell-therapy-technologies/clinical-trial-data-visuali…

Format: Website
Years Covered: Cumulative to 2017/02/01
Search Strategy: Software search registry by keywords,
augmented by human evaluation
Project Focus: MSC trials only from ClinicalTrials.gov
Special Notes: on-line sort by 6 parameters

14 2597 2017 YES varies gene therapy ClinicalTrials.gov & WHO registries

Ginn SL, et al. J Gene Medicine 2018; 20(5):e3015

Link: https://onlinelibrary.wiley.com/doi/abs/10.1002/jgm.3015

Format: Publication
Years Covered: 1989 - 2017
Search Strategy: Manually search registries by keywords
Project Focus: Review gene therapy trials combining cellular therapy and in vivo therapy

15 416 2017 YES Perinatal ALL ClinicalTrials.gov & WHO registries

Verter F, Couto PS, Bersenev A. Future Science 2018; 4(10):Editorial

Link: https://www.future-science.com/doi/full/10.4155/fsoa-2018-0085

Format: Publication
Years Covered: Jan. 2005 - Dec. 2017
Search Strategy: Manually search a dozen registries by keywords
Project Focus: Trials of perinatal cells for advanced cell therapy, worldwide

16 178 2017 YES UC-MSC ALL ClinicalTrials.gov & WHO registries

Couto PS, Shatirishvili G, Bersenev A, Verter F. Regenerative Medicine 2019; open access

Link: https://www.futuremedicine.com/doi/full/10.2217/rme-2018-0171

Format: Publication
Years Covered: Jan. 2007 - Dec. 2017
Search Strategy: Manually search a dozen registries by keywords
Project Focus: Link first decade of UC-MSC trials to UC-MSC publications
Special Notes: First review of manufacturing methods in UC-MSC publications

17 57 2016 NO Cord Blood novel Misc.

Rizk M et al. Biol Blood Marrow Transplant. 2017; 23(10):1607-1613

Link: http://www.sciencedirect.com/science/article/pii/S1083879117304986

Format: Publication
Years Covered: Cumulative to June 2016
Search Strategy: Searched publications to find trials
Project Focus: Cord Blood trials, "novel" therapy, registered anywhere

18 109 2016 NO UC-MSC ALL ClinicalTrials.gov

Davies J, Walker JT, Keating A. Stem Cells Trans Med 2017; 6(7):1620-1630

Link: http://onlinelibrary.wiley.com/doi/10.1002/sctm.16-0492/full

Format: Publication
Years Covered: 2009 - 2016
Search Strategy: Manually search registry by keywords
Project Focus: Trials that employ umbilical cord tissue MSC

19 106 2016 NO CAR-T ALL ClinicalTrials.gov & EudraCT

de Wilde S, et al. Cytotherapy 2017; 19(6):703-709

Link: http://www.celltherapyjournal.org/article/S1465-3249(17)30524-8/fulltext

Format: Publication
Years Covered: Cumulative to June 2016
Search Strategy: Manually search registries by keywords
Project Focus: Only CAR-T trials conducted in Canada, US, EU
Special Notes: 49 of 106 trials moved to subsequent trial

20 12 2016 YES AT-MSC aesthetic surgery ClinicalTrials.gov &WHO registries

Arshad Z, et al. Aesthet Surg J 2017; epub

Link: https://www.ncbi.nlm.nih.gov/pubmed/28591768

Format: Publication
Years Covered: Cumulative to 2016/12/31
Search Strategy: Manually search all world registries by keywords
Project Focus: only AT-MSC trials for aesthetic surgery
Special Notes: supplement provides 115 patent applications 2002-2016

21 220 2016 YES CAR-T ALL ClinicalTrials.gov

Hartmann J et al. EMBO Molecular Medicine 2017; e201607485

Link: http://embomolmed.embopress.org/content/early/2017/07/31/emmm.201607485.long

Format: Publication
Years Covered: Cumulative to end of 2016
Search Strategy: Manually search registry by keywords
Project Focus: Review of CAR-T trials, distinguishes ongoing from non-active trials, includes trial outcomes, provides download of the 220 trials with 10 parameters per trial
Special Notes: First trial compilation ever to give away raw trial data.

22 34 2014 NO MSC cardiac ClinicalTrials.gov

Sanina C, Hare JM. Circulation Research. 2015;117:229-233

Link: http://circres.ahajournals.org/content/117/3/229.short

Format: Publication
Years Covered: not disclosed
Search Strategy: Manually search registry by keywords
Project Focus: MSC cardiac trials only from ClinicalTrials.gov

23 41 2014 NO ALL ALL UK Catapult

Bisson I et al. Regenerative Medicine 2015; 10(2):169-179

Link: http://www.futuremedicine.com/doi/abs/10.2217/rme.14.71

Format: Publication
Years Covered: April 2013 - March 2014
Search Strategy: Manually search 4 registries by keywords
Project Focus: Only UK trials with status Open
Special Notes: Build UK Catapult from searches of
USA:ClinicalTrials.gov, UK:ISRCTN, UK:CRN, EudraCT

24 278 2014 NO ALL ALL EudraCT

de Wilde S, et al. Mol Ther Methods Clin Dev. 2016; 3:16073.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130079/

Format: Publication
Years Covered: 2004 - 2014
Search Strategy: Manually search registry by keywords
Project Focus: Decadal review of EU trials only
Special Notes: 278 trials covered 198 products

25 469 2014 NO see notes ALL Misc.

Trounson A, McDonald C. Cell Stem Cell 2015; 17(1):11-22

Link: http://www.sciencedirect.com/science/article/pii/S1934590915002672

Format: Publication
Years Covered: not disclosed
Search Strategy: Searched publications to find trials
Project Focus: trials are listed for the 3 cell types ESC, placental, neural

26 724 2014 NO ALL ALL ClinicalTrials.gov

Heathman TRJ et al. Regenerative Medicine 2015; 10(1):49-64

Link: http://www.futuremedicine.com/doi/full/10.2217/rme.14.73

Format: Publication
Years Covered: Cumulative to 2014
Search Strategy: Manually search registry by keywords
Project Focus: all cell therapy trials in ClinicalTrials.gov
Special Notes: Found 1342 cell therapy trials with status Open, eliminate 46% (618) that are "oncology"

27 1058 2012 YES ALL novel ClinicalTrials.gov &WHO registries

Li MD, Atkins H, Bubela T. Regenerative Medicine 2014; 9(1):27-39

Link: http://www.futuremedicine.com/doi/full/10.2217/rme.13.80

Format: Publication
Years Covered: 1992 - 2012
Search Strategy: Manually search registries by keywords
Project Focus: Two Decades review of the world
Special Notes: Found 4749 cell therapy trials total, but only 1058 are "novel" therapy

28 344 2012 YES MSC ALL ClinicalTrials.gov

Wei X et al. Acta Pharmacologica Sinica 2013; 34:747–754

Link: http://www.nature.com/aps/journal/v34/n6/abs/aps201350a.html

Format: Publication
Years Covered: 2004 - 2012
Search Strategy: Manually search registry by keywords
Project Focus: MSC trials only from ClinicalTrials.gov

29 218 2012 NO MSC ALL ClinicalTrials.gov

Sharma et al. Transfusion 2013; 54(5):1418–1437

Link: http://onlinelibrary.wiley.com/doi/10.1111/trf.12421/full

Format: Publication
Years Covered: Cumulative to 2012/10/22
Search Strategy: Manually search registry by keywords
Project Focus: MSC trials only from ClinicalTrials.gov

30 1052 2012 NO None ALL ClinicalTrials.gov & WHO registries

Fung M et al. 2017; Stem Cell Reports 8:1190-1201

Link: http://www.cell.com/stem-cell-reports/pdf/S2213-6711(17)30119-4.pdf

Format: Publication
Years Covered: 1992 - 2012
Search Strategy: Seek publications and outcomes from trials in Li, Atkins, Bubela 2014
Project Focus: Follow up to prior trial compilation to learn how many regenerative medicine trials completed (37.4%), and published (45.4% of completed), and did the trials follow ISSCR guidelines?
Special Notes: This study is 1st of its kind.
 

31 1716 2010 NO ALL ALL ClinicalTrials.gov

Culme-Seymour EJ et al. Regenerative Medicine 2012; 7(4):455-462

Link: http://www.futuremedicine.com/doi/full/10.2217/rme.12.45

Format: Publication
Years Covered: Feb 2000 - June 2010
Search Strategy: Manually search registry by keywords
Project Focus: Decadal review ClinicalTrials.gov
Special Notes: Found 2724 cell therapy trials total,
eliminate 37% (1008) that are "conventional grafts"

32 318 2010 NO ALL ALL EudraCT

Maciulaitis R et al. Mol Ther. 2012; 20(3):479-82.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293601/

Format: Publication
Years Covered: May 2004 - Dec 2010
Search Strategy: Manually search registry by keywords
Project Focus: EU trials only

33 123 2011 NO MSC ALL ClinicalTrials.gov

Trounson A et al. BMC Medicine 2011; DOI:10.1186/1741-7015-9-52

Link: http://bmcmedicine.biomedcentral.com/articles/10.1186/1741-7015-9-52

Format: Publication
Years Covered: Cumulative to 2011/02/08
Search Strategy: Manually search registry by keywords
Project Focus: MSC trials only from ClinicalTrials.gov

34 103 2013 NO ALL ALL Misc.

Ratcliffe E. et al. Br Med Bull 2013; 108:73-94

Link: http://bmb.oxfordjournals.org/content/early/2013/11/07/bmb.ldt034.short

Format: Format: Publication
Years Covered: Cumulative to April 2013
Search Strategy: Manually search USA FDA CBER report & UK Catapult database
Project Focus: trials review USA & UK trials only

35 196 2013 YES ALL ALL ClinicalTrials.gov

The Stem Cell Stock Index by Busa Consulting

Link: http://busaconsultingllc.com/scsi/organelles/2013_clinical_trials_almanac.php, http://busaconsultingllc.com/scsi/organelles/2013_clinical_trials_multiheatmap…

Format: Website 
Years Covered: Cumulative from 1998 to 2013/08/31
Search Strategy: Manually search registry by keywords
Project Focus: only trials sponsored by industry
Special Notes: on-line heat-map display

36 347 2013 YES MSC ALL ClinicalTrials.gov

Ankrum JA, Ong JF, Karp JM. Nat Biotechnol. 2014 Mar; 32(3):252–260

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320647/

Format: Publication
Years Covered: 2000 - 2013
Search Strategy: Manually search registry by keywords
Project Focus: 14yrs MSC trials only from ClinicalTrials.gov

37 47 2013 NO Cord Blood novel Misc.

Iafolla MA, Tay J, Allan DS. Biol Blood Marrow Transplant. 2014; 20(1):20-25

Link: http://www.bbmt.org/article/S1083-8791(13)00409-6/fulltext

Format: Publication
Years Covered: Cumulative to 2013
Search Strategy: Searched publications to find trials
Project Focus: Cord Blood trials, "novel" therapy, status Open, registered anywhere

38 493 2015 NO MSC ALL ClinicalTrials.gov

Squillaro T, Peluso G, Galderisi U. 2016; Cell Transplantation 25:829-848

Link: https://journals.sagepub.com/doi/full/10.3727/096368915X689622

Format: Publication
Years Covered: Cumulative to 2015/06/15
Search Strategy: Manually search registry by keywords
Project Focus: MSC trials only from ClinicalTrials.gov

39 1579 2015 YES ALL immuno-therapy ClinicalTrials.gov & WHO registries

Bonter K, ... Bubela T. Regenerative Medicine 2017; 12(6):623-636

Link: https://www.futuremedicine.com/doi/pdfplus/10.2217/rme-2017-0031

Format: Publication
Years Covered: 1974 - 2015
Search Strategy: Computer search registries by keywords, followed with manual review
Project Focus: Trends in immunotherapy, especially academic versus industry development
Special Notes: Trial screening identified "interventional trials" that measure at least one: safety, tolerability, efficacy.

40 281 2015 YES Perinatal ALL ClinicalTrials.gov & WHO registries

Couto PS, Bersenev A, Verter F. Regenerative Medicine 2017; 12(8):953-968

Link: https://www.futuremedicine.com/doi/pdf/10.2217/rme-2017-0066

Format: Publication
Years Covered: Jan. 2005 - Dec. 2015
Search Strategy: Manually search a dozen registries by keywords
Project Focus: Trials of perinatal cells for advanced cell therapy, worldwide
Special Notes: First paper on first decade of perinatal advanced cell therapy

41 39 2015 NO MSC pediatric Misc.

Nitkin CR, Bonfield TL. Stem Cells Transl Med 2017; 6(2):539–565

Link: http://onlinelibrary.wiley.com/doi/10.5966/sctm.2015-0427/full

Format: Publication
Years Covered: 2002 - 2015
Search Strategy: Searched publications to find trials
Project Focus: MSC pediatric trials only
Special Notes: among 39 trials only 13 are registered

42 939 2015 partialYES ALL ALL ClinicalTrials.gov

Monsarrat P et al. Stem Cells Transl Med 2016; 5(6):826-35

Link: http://stemcellstm.alphamedpress.org/content/early/2016/04/13/sctm.2015-0329.ab…, http://multireview.perso.sfr.fr

Format: Publication
Years Covered: Cumulative to 2015/06/29
Search Strategy: Software search registry by MeSH code
Project Focus: all trials from ClinicalTrials.gov
Special Notes: companion website available for MeSH search, time trends combine multiple years, among 939 trials 51.1% (480) were cell type MSC

43 41 2015 NO MSC cardiac ClinicalTrials.gov

Singh A, Singh A, Sen D. Stem Cell Research & Therapy (2016) 7:82

Link: http://stemcellres.biomedcentral.com/articles/10.1186/s13287-016-0341-0

Format: Publication
Years Covered: 2010 - 2015
Project Focus: MSC cardiac trials only from ClinicalTrials.gov
Special Notes: open source article has link to download table of all trials

44 177 2015 NO SVF-MSC ALL ClinicalTrials.gov

Feisst V, Meidinger S, Locke MB. Stem Cells Cloning 2015; 8:149–162

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636091/

Format: Publication
Years Covered: Cumulative to May 2015
Search Strategy: Manually search registry by keywords
Project Focus: SVF-MSC trials only from ClinicalTrials.gov
Special Notes: found 177 trials, 89 with status Open

45 152 2015 YES SVF-MSC ALL ClinicalTrials.gov

Nordberg RC, and Loboa EG. Stem Cells Transl Med. 2015; 4(9):974–979

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542878/

Format: Publication
Years Covered: Cumulative to 2015/03/09
Search Strategy: Manually search registry by keywords
Project Focus: SVF-MSC trials only from ClinicalTrials.gov
Special Notes: provides database of companies and patents